Immunology - M1

diagram of helper t cell

Image adapted from the National Cancer Institute. This image is in the Public Domain.

Term:
Winter 2009
Published:
January 19, 2010
Revised:
June 5, 2015

This sequence explores the elements of innate and acquired immune defense mecahnisms, the cells involved, their development and maturation, and biomolecular cellular communication mechanisms required to successfully fight off infection.

Sequence Director:
Wesley Dunnick, Ph.D.

dScribes:
Reda Jaber
Wassim Chehouri
Matthew Wixson

Syllabus

Grading

This sequence will be graded as pass/fail. Students will receive a single cumulative grade for the sequence, based a quiz and final exam. Each quiz and examination question is worth one point. In order to pass the sequence a student must achieve a cumulative score of at least 75%.

Total Questions (approximate)

Quiz (2/23) - Week 1

Lectures - 28
Small Group - 2
Laboratories - 8
Complement, Transplantation Allergy/Asthma Self Studies - 2

Final (3/2) - Week 1
Lectures - 28
Small Group - 2
Laboratories - 4
Complement, Transplantation Allergy/Asthma Self Studies - 2

Final (3/2) - Week 2
Lectures - 30
Small Group - 2
Laboratories - 20-24
Complement, Transplantation Allergy/Asthma Self Studies - 6

Small Groups

The Immunology Sequence includes three one-hour small groups which are run differently than small groups in other sequences. Your attendance at small groups is not required. The material to be presented is important, particularly to place the details you learn about immune responses in lecture into the context of a larger picture and into the context of a real clinical situation. There will be two exam or quiz questions asked for each small group session. Each small group has a unique leader, and hence each small group experience is unique. The small group leaders are aware of the quiz/exam questions to be posed, and will be sure to cover that specific material (which is very likely to arise naturally during the discussion questions).

Beyond that part of the material, the discussion in each small group will depend on both the leader and the student’s questions about the material. Hence, it would be impossible to condense all of the small group experiences into a common document. Therefore, there will be no materials (other than the Multiple Myeloma Powerpoint) posted online for these small groups. Your only way to obtain the experience is to attend.

Required Textbook

  • Robbins Pathologic Basis of Disease. Cotran, Kumar, and Robbins (Saunders)

Recommended Textbook

  • The Immune System. - P. Parham (second edition, Garland Science.) 2005. ISBN: 0-8153-4093-1

We strongly recommend that you purchase some basic Immunology text for this course. The Parham text (above) has about the right depth for this class. You might be able to use any other text that is less than four years old. For example, Janeway et al., Abbas et al.

 

Course Faculty

  • Wesley Dunnick, Ph.D. (Course Director) - Department of Microbiology and Immunology
  • Cheong-Hee Chang, Ph.D. - Department of Microbiology and Immunology
  • Joseph C. Fantone, M.D. - Department of Pathology
  • Massimo T. Pietropaolo, M.D. - Internal Medicine and Pediatrics and Communicable Diseases
  • Lloyd M. Stoolman, M. D. - Department of Pathology
  • Thomas R. Gest, Ph. D. - Medical Education
  • J. Matthew Velkey, Ph. D. - Cell and Developmental Biology

Learning Outcomes

  1. To understand the structural and genetic basis of diversity and specificity of immunoglobulins and T cell receptors.
  2. To understand the utility of antibodies in many clinical tests for proteins, hormones, etc.
  3. To understand the events that hallmark the antigen-independent and antigen-dependent phases of B cell differentiation.
  4. To understand the diversity of MHC molecules, and how that diversity differs from immunoglobulin and T cell receptor diversity.
  5. To understand how MHC molecules present antigens, and how antigens are processed to before presentation.
  6. To understand positive and negative T cell selection in the thymus, and how those events influence the final T cell repertoire.
  7. To understand the requirements for T cell activation by antigen, and how the nature of the antigen presenting cell influences the outcome of antigen recognition.
  8. To understand that transplantation reactions are mainly the result of cell recognition of allogeneic MHC molecules.
  9. To understand how the effector functions of antibodies, T cells, macrophages, neutrophils, and NK cells can eliminate pathogens or lead to pathology.
  10. To understand the function of CD4+ Th1, CD4+ Th2 cells, and CD8+ cytotoxic T cells in the immune response.
  11. To appreciate the multiple roles of cytokines and chemokines in mediating interactions between leukocytes and other leukocytes and between leukocytes and other types of cells.
  12. To understand how cells in both innate and acquired immunity can encounter a pathogen first at one site, and then fight an infection at some distal site.

Reading List

Required Textbook

  • Robbins Pathologic Basis of Disease. Cotran, Kumar, and Robbins (Saunders)

Recommended Textbook

  • The Immune System. - P. Parham (second edition, Garland Science.) 2005. ISBN: 0-8153-4093-1

We strongly recommend that you purchase some basic Immunology text for this course. The Parham text (above) has about the right depth for this class. You might be able to use any other text that is less than four years old. For example, Janeway et al., Abbas et al.

diagram of helper t cell

Image adapted from the National Cancer Institute. This image is in the Public Domain.

Term:
Winter 2009
Published:
January 19, 2010
Revised:
June 5, 2015

Syllabus

Document Title Creator Downloads License

Syllabus

Wesley Dunnick

Lectures

Document Title Creator Downloads License

02.09.09(a): Case Study: Type I Diabetes Overview of Immune Response

Dept. Staff

02.09.09(b): Antibodies

Dept. Staff

02.09.09(c): Antibody-Based Clinical Tests

Dept. Staff

02.10.09(a): Self-Study: The Complement System in Human Disease

Joe Fantone

02.10.09(b): Phagocytic Cells: Mechanisms of Bacterial Injury and Tissue Injury

Joe Fantone

02.10.09(c): Arachadonic Acid Metabolism

Joe Fantone

02.10.09(d): B-Cell Development

Dept. Staff

02.11.09(a): Joining Variable & Constant Region Genes

Dept. Staff

02.11.09(b): B-Cell Differentiation

Dept. Staff

02.12.09: Multiple Myeloma

Dept. Staff

02.13.09(a) Cytokines

Dept. Staff

02.13.09(b): T-Cell Development

Dept. Staff

02.16.09: Lymphatic Histology

Matthew Velkey

02.17.09(a): Types I - IV Immunopathology

Joe Fantone

02.17.09(b): Self Study: Allergy & Asthma

Dept. Staff

02.17.09(c): Self Study: Transplantation

Dept. Staff

02.18.09: Review: Type 1 Diabetes and Overview of Immune Response

Dept. Staff

Schedules

Document Title Creator Downloads License

2007 Daily Schedule: M1 Immunology

Dept. Staff

2008 Daily Schedule: M1 Immunology

Dept. Staff

2009 Daily Schedule: M1 Immunology

Dept. Staff

2010 Daily Schedule: M1 Immunology

Dept. Staff

Student Notes

Document Title Creator Downloads License

02.11.08(a): Sequence Intro Immunology

Aken Desai
Michael Mathis

02.11.08(b): Antibody Structure and Function

Aken Desai
Michael Mathis

02.11.08(c): Antibody-Based Clinical Tests

Aken Desai
Michael Mathis

02.12.08(a): Complement Self-Study Module

Aken Desai
Michael Mathis

02.12.08(b): Phagocytic Cells: Mechanisms of Bacterial Killing and Tissue Injury

Aken Desai
Michael Mathis

02.12.08(c): Arachidonic Acid Metabolites and Inflammation

Aken Desai
Michael Mathis

02.12.08(d): B Cell Development and Activation

Aken Desai
Michael Mathis

02.12.08: Anterior Triangle of the Neck

Aken Desai
Michael Mathis

02.13.08(a): Joining Variable and Constant Regions

Aken Desai
Michael Mathis

02.13.08(b): Eventsin Antigen Driven B Cell Differentiation

Aken Desai
Michael Mathis

02.13.08(c): T Cell Antigen Receptor

Aken Desai
Michael Mathis

02.13.08: Posterior Triangle of the Neck

Aken Desai
Michael Mathis

02.14.08: Small Group: Processing and Presentation of Antigens for TCR Recognition and Myeloma

Aken Desai
Michael Mathis

02.15.08(a): Cytokines and Chemokines

Aken Desai
Michael Mathis

02.15.08(b): The MHC Complex

Aken Desai
Michael Mathis

02.15.08(c): T Cell Development

Aken Desai
Michael Mathis

02.18.08(a): T Cell Activation

Aken Desai
Michael Mathis

02.18.08(b): T Cell Effector Function

Aken Desai
Michael Mathis

02.18.08: Histology - Lymphatic System

Aken Desai
Michael Mathis

02.19.08(a): Type I Diabetes

Aken Desai
Michael Mathis

02.19.08(b): Classification of Immune Mediated Tissue Injury

Aken Desai
Michael Mathis

02.19.08(c): Small Group: Hyper-IgM Agammaglobulinemia

Aken Desai
Michael Mathis

02.19.08(d): Allergy and Asthma Self-Study Module

Aken Desai
Michael Mathis

02.19.08(e): Transplantation Self Study

Aken Desai
Michael Mathis

02.20.08: Small Group: Leukocyte Development and Trafficking During Inflammation and Immunity + Myasthenia Gravis

Aken Desai
Michael Mathis